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Recombinant Human Janus Kinase 1

Involved in cytokine-mediated signaling
Catalog #: P1678
SKU-Size Size Price Qty
P1678-10 10 µg
$295.00
P1678-50 50 µg
$425.00
More Sizes Get Quote

Product Details

Alternate Name Tyrosine-protein kinase JAK1, JAK1, JAK1A, JAK1B
Gene ID 3716
Accession # P23458
Source Insect Cells (sf9)
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 37.25 kDa
Purity by SDS-PAGE ≥ 95%
Formulation 50 mM Tris pH 7.5, 150 mM NaCl, 0.1mM EDTA, 2 mM DTT in 35% Glycerol
Amino Acid Sequence aa 843 – 1154 with C-terminal His tag
Specific Activity > 50 mU/mg
Unit Definition One unit is the amount of enzyme that generates 1 µmole of ADP per minute at pH 7.2 at 37 °C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Janus Kinase 1, also known as JAK1, is a member of the Janus kinase (JAK) family, one of ten recognized non-receptor tyrosine kinase families. It uses the JAK-STAT pathway to transduce cytokine-mediated signals. The enzyme has two phosphate-transferring domains that are near-identical. One domain exhibits kinase activity, while the other regulates the kinase activity of the first. JAK inhibitors are being studied for the treatment of atopic dermatitis, essential thrombocythemia, rheumatoid arthritis, polycythemia vera, psoriasis, alopecia, ulcerative colitis, etc.


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