Recombinant Bovine Coronavirus Hemagglutinin-esterase (HE)

Structural protein that makes short spikes at the surface of the virus.
Catalog #: P1527 | abID:

Product Details

Alternate Name Hemagglutinin-esterase, HE protein, E3 glycoprotein, HE
Accession # P15776
Source Yeast
Appearance Liquid
Physical Form Description Clear solution
Molecular Weight 47.0 kDa (N-terminal 6xHis-tag)
Purity by SDS-PAGE >90%
Amino Acid Sequence aa 19-424
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Structural protein that makes short spikes at the surface of the virus. It contains receptor binding and receptor-destroying activities and mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps to prevent self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. It seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system.

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