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recMAb™ Anti-PMS2 Antibody

Recombinant rabbit monoclonal antibody to detect PMS2 expression in human samples
Catalog #: A2223
$395.00

Product Details

Cat # +Size A2223-100
Size 100 μg
Antibody Target PMS2
Alternate Name MLH4, PMSL2, HNPCC4, PMS2CL, H_DJ0042M02.9
Host Rabbit
Antibody Type Monoclonal
Isotype IgG
Immunogen Synthetic peptide targeting residues within aa 1-100 of PMS2
Accession # P54278
Gene ID 5395
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 10 mM PBS
Purification Protein A/G purified
Species Reactivity Human
Application Immunohistochemistry (IHC)
Application & Usage IHC (1-2 µg/ml)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.


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