RalA and RalB GTPase inhibitor
Catalog #: B1136 | abID:

Product Details

Alternate Name 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Appearance White Solid
CAS # 361185-42-4
Molecular Formula C₂₅H₂₀N₄O₃
Molecular Weight 424.45
Purity ≥98% by HPLC
Solubility DMSO (> 40 mg/ml)
InChi 1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)
PubChem CID 6626226
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the activation of RaiA in living cells Ral is needed for the growth of murine embryonic fibroblasts (MEFs). Ral pull down assay showes that RBC8 inhibits the activation of both RalA and RalB in the H2122 and H358 cell lines.

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