Product Details
| Cat # +Size | 6154-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | RBBP4 |
| Alternate Name | NURF55, RBAP48 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant protein of human RBBP4 |
| Accession # | Q09028 |
| Gene ID | 5928 |
| Appearance | Colorless liquid |
| Concentration | 1 mg/ml |
| Formulation | 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot, Immunohistochemistry |
| Positive Control | Western Blot: Various cell lysates |
| Application & Usage | Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Retinoblastoma associated proteins 46 and 48 (RBAP46 and RBAP48; also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein. Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication. RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone deacetylation complex NuRD, and the Sin3/HDAC histone deacetylation complex. More recently, RBAP46 and RBAP48 were identified as components of the polycomb repressor complex PRC2, which also contains EED and Ezh2. RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone deacetylation complexes to their histone substrates.
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