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RBBP4 Antibody

Polyclonal antibody to detect RBBP4 in human, mouse and rat samples.
Catalog #: 6154
$335.00

Product Details

Cat # +Size 6154-100
Size 100 μg
Antibody Target RBBP4
Alternate Name NURF55, RBAP48
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein of human RBBP4
Accession # Q09028
Gene ID 5928
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Positive Control Western Blot: Various cell lysates
Application & Usage Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Retinoblastoma associated proteins 46 and 48 (RBAP46 and RBAP48; also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein. Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF­1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication. RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone de­acetylation complex NuRD, and the Sin3/HDAC histone de­acetylation complex. More recently, RBAP46 and RBAP48 were identified as components of the polycomb repressor complex PRC2, which also contains EED and Ezh2. RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone de­acetylation complexes to their histone substrates.


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