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Rat Renin Inhibitor Screening Kit (Fluorometric)

Sensitive Assay to Screen Rat Renin Inhibitors, HTS
Catalog #: K798

Product Details

Cat # +Size K798-100
Size 100 assays
Detection Method Fluorescence (Ex/Em = 328/552 nm)
Applications Screening potential inhibitors of rat renin
Characterize/study rat renin inhibitors
Features & Benefits • Rapid & HTS
• Reliable test for screening/studying/characterizing potential inhibitors of rat renin
• Includes Inhibitor Control
Kit Components • Renin Assay Buffer
• Rat Renin Substrate
• Rat Renin Enzyme (lyophilized)
• Rat Renin Inhibitor (lyophilized)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Renin (EC, also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Rat Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Rat Renin inhibitor, the rate of hydrolysis of the substrate is decreased or inhibited. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of rat renin inhibitors. It is also adaptable to a 384-well format.

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