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Rat Renin Inhibitor Screening Kit (Fluorometric)

Sensitive Assay to Screen Rat Renin Inhibitors, HTS
Catalog #: K798
$625.00

Product Details

Cat # +Size K798-100
Size 100 assays
Detection Method Fluorescence (Ex/Em = 328/552 nm)
Applications Screening potential inhibitors of rat renin
Characterize/study rat renin inhibitors
Features & Benefits • Rapid & HTS
• Reliable test for screening/studying/characterizing potential inhibitors of rat renin
• Includes Inhibitor Control
Kit Components • Renin Assay Buffer
• Rat Renin Substrate
• Rat Renin Enzyme (lyophilized)
• Rat Renin Inhibitor (lyophilized)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Rat Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Rat Renin inhibitor, the rate of hydrolysis of the substrate is decreased or inhibited. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of rat renin inhibitors. It is also adaptable to a 384-well format.


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