Product Details
| Alternate Name | 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus |
|---|---|
| Appearance | White to Off-white solid |
| CAS # | 53123-88-9 |
| Molecular Formula | C₅₁H₇₉NO₁₃ |
| Molecular Weight | 914.19 |
| Purity | ≥99% |
| Solubility | DMSO and EtOH |
| SMILES | CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC |
| InChi | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
| InChi Key | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| PubChem CID | 5284616 |
| MDL Number | MFCD00867594 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An immunosuppressant. Selectively blocks signaling that leads to p70 S6 kinase activation (IC₅₀ = 50 pM). Inhibits lymphokine-induced cell proliferation at the G1 phase. Induces apoptosis in a murine B cell line. Rapamycin has been used in vivo studies by i.p., i.m., and i.v. administrations..
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Marisa Stebegg, Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. eLife., Mar. 2020; 32204792.
Fei Liu, et al.,(2018) miR-92b promotes autophagy and suppresses viability and invasion in breast cancer by targeting EZH2, International Journal of Oncology, Oct. 2018, 30066891
Totary-Jain, H. et al. Rapamycin Resistance Is Linked to Defective Regulation of Skp2, Cancer Res., Apr 2012; 72: 1836 - 1843.
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