Product Details
| Cat # +Size | 5323-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | RANTES |
| Alternate Name | Chemokine, CC motif, ligand 5, CCL5, CCL-5, CCL 5 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | E. coli-expressed mature rat RANTES (a.a. 1-70) |
| Accession # | NP_112378 |
| Gene ID | 81780 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-RANTES polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Mouse, rat |
| Application | Western blot |
| Application & Usage | Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. RAW264.7 cells treated with LPS (15 hr) can be used as a positive control. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
RANTES (regulated upon activation, normal T-cell expressed and secreted) is a 70-amino acid CC chemokine originally cloned from T-cell-specific sequences-enriched cDNA libraries. Both human and murine RANTES are chemotactic for monocytes. Human RANTES is also a chemoattractant for T-cells and eosinophils, as well as an activator of basophils for histamine release. In contrast to other CC chemokines, RANTES is only slowly expressed after activation of leukocytes. It is involved in a number of pathological conditions like chronic inflammation and autoimmune diseases.
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