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RAF265

A potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E
Catalog #: 2856
SKU-Size Size Price Qty
2856-5 5 mg
$125.00
2856-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 1-Methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine; CHIR265
Appearance Light yellow to yellow solid
CAS # 927880-90-8
Molecular Formula C₂₄H₁₆F₆N₆O
Molecular Weight 518.41
Purity ≥98% by HPLC
Solubility DMSO (>100 mg/ml)
SMILES CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
InChi InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
InChi Key YABJJWZLRMPFSI-UHFFFAOYSA-N
PubChem CID 11656518
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.


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