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RAF1, Active

A proto-oncogene 
Catalog #: 7726
SKU-Size Size Price Qty
7726-5 5 μg
$295.00
7726-100 100 μg
$3,950.00
More Sizes Get Quote

Product Details

Alternate Name RAF, RAF proto-oncogene serine/threonine-protein kinase , Proto-oncogene c-RAF
Gene Symbol RAF1
Gene ID 5894
Accession # P04049
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Weight 63.0 kDa
Purity by SDS-PAGE ≥85%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

RAF1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly (1). The activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration (2).


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