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Radicicol

An antifungal antibiotic and heat shock protein 90 (Hsp90) inhibitor
Catalog #: B1533
SKU-Size Size Price Qty
B1533-1 1 mg
$135.00
B1533-5 5 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name KF9-A, KF58332, Monorden, NSC 294404
Appearance White solid
CAS # 12772-57-5
Molecular Formula C₁₈H₁₇ClO₆
Molecular Weight 364.78
Purity ≥98%
Solubility DMSO (>20 mg/ml)
SMILES CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
InChi InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
InChi Key WYZWZEOGROVVHK-GTMNPGAYSA-N
PubChem CID 6323491
MDL Number MFCD06795865
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Radicicol is an antifungal antibiotic that inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis. Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.


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