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R428

A potent and selective AXL kinase Inhibitor
Catalog #: 9591
SKU-Size Size Price Qty
9591-5 5 mg
$195.00
9591-25 25 mg
$735.00
More Sizes Get Quote

Product Details

Alternate Name 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine;BGB324
Appearance Crystalline solid
CAS # 1037624-75-1
Molecular Formula C₃₀H₃₄N₈
Molecular Weight 506.64
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
InChi InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1
InChi Key KXMZDGSRSGHMMK-VWLOTQADSA-N
PubChem CID 46215462
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

R428 is a potent and selective small-molecule inhibitor (IC₅₀ = 14 nM) of the receptor tyrosine kinase Axl. R428 blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.


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