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An inhibitor of spleen tyrosine kinase (Syk)
Catalog #: B2913
SKU-Size Size Price Qty
B2913-5 5 mg
B2913-25 25 mg
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Product Details

Alternate Name 3-[[5-fluoro-2-(3-hydroxyanilino)pyrimidin-4-yl]amino]phenol; (E)-Elafibranor; 3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)diphenol; N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-primidinediamine; 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol
Appearance A crystalline solid
CAS # 575474-82-7
Molecular Formula C₁₆H₁₃FN₄O₂
Molecular Weight 312.3
Purity > 98%
Solubility ~30 mg/ml in DMSO
InChi InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
PubChem CID 9904854
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


R112 is an inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 226 nM in cultured human mast cells. It is an ATP-competitive Syk inhibitor with a Ki of 96 nM. It completely and rapidly inhibits all mast cell activation cascades triggered by IgE receptor cross-linking: degranulation, lipid mediator production, and cytokine production.

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