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(R,S)-Lenalidomide

based on 1 citations in multiple journals(R,S)-Lenalidomide14.1 4
Tumor Necrosis Factor-α (TNF-α) inhibitor
Catalog #: 1862
SKU-Size Size Price Qty
1862-25 25 mg
$75.00
1862-100 100 mg
$180.00
More Sizes Get Quote

Product Details

Alternate Name (R,S)-3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Appearance White to off-white solid
CAS # 191732-72-6
Molecular Formula C₁₃H₁₃N₃O₃
Molecular Weight 259.26
Purity ≥98% by HPLC
Solubility DMSO (~100 mg/ml)
SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
InChi InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChi Key GOTYRUGSSMKFNF-UHFFFAOYSA-N
PubChem CID 216326
MDL Number MFCD07772307
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting Tumor Necrosis Factor-α (TNF-α). Displays potent anti-tumor and anti-inflammatory effects as well as modulates and potentiates host immune responses against multiple myeloma.


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Cinzia Fionda et al.,Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell–Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3.J. Immunol., Jun 2013; 190: 6662 - 6672.
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