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(R,R)-Hymeglusin

A specific and irreversable inhibitor of HMG-CoA
Catalog #: B1244
SKU-Size Size Price Qty
B1244-500 500 µg
$225.00
B1244-1000 1 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name (2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
Appearance White to off-white solid
CAS # 29066-42-0
Molecular Formula C₁₈H₂₈O₅
Molecular Weight 324.41
Purity ≥95% by HPLC
Solubility DMSO
SMILES CC(CCCCC1C(C(=O)O1)CO)CC(=CC(=CC(=O)O)C)C
InChi InChI=1S/C18H28O5/c1-12(8-13(2)9-14(3)10-17(20)21)6-4-5-7-16-15(11-19)18(22)23-16/h9-10,12,15-16,19H,4-8,11H2,1-3H3,(H,20,21)/b13-9+,14-10+/t12-,15-,16-/m1/s1
InChi Key ODCZJZWSXPVLAW-KXCGKLMDSA-N
PubChem CID 6440895
MDL Number MFCD01940046
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

(R,R)-Hymeglusin is a specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. It is a fungal beta-lactone that inhibits mevalonate biosynthesis and is a good target for statins. It displays antimicrobial and anti-fungal activity.


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