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(R)-Bicalutamide

An androgen antagonist
Catalog #: B2173
SKU-Size Size Price Qty
B2173-5 5 mg
$75.00
B2173-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Appearance White to off-white solid
CAS # 113299-40-4
Molecular Formula C₁₈H₁₄F₄N₂O₄S
Molecular Weight 430.37
Purity ≥98%
Solubility DMSO
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
InChi InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1
InChi Key LKJPYSCBVHEWIU-KRWDZBQOSA-N
PubChem CID 56069
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

R-Bicalutamide is a first-generation antiandrogen that inhibits androgen action by competitively binding to the androgen receptor (AR). With other anti-androgens, R-bicalutimide decreases levels of Bcl-2, Bcl-XL, caspase-3, and PARP, induces apoptosis, and inhibits cell growth of prostate cancer cells. In similar animal models, this compound decreases plasma PSA levels and suppresses tumor growth. Bicalutamide binds the androgen receptor in two sites, distorting coactivator binding and inhibiting transcription.


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