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An inhibitor of signaling through the TNFα receptor complex
Catalog #: B3063
SKU-Size Size Price Qty
B3063-1 1 mg
B3063-5 5 mg
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Product Details

Alternate Name TNF-alpha Antagonist III; 8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline; 8-chloro-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxalin-4-yl phenyl sulfide
Appearance Beige to Yellow Solid
CAS # 303997-35-5
Molecular Formula C₁₆H₈ClF₃N₄S
Molecular Weight 380.77
Purity ≥98%
Solubility ~10 mg/ml in DMF; ~1 mg/ml in DMSO
InChi InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
PubChem CID 1486608
MDL Number MFCD00140737
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor interacting protein 1 (RIP1) through inhibition of ligand-induced receptor endocytosis. It inhibits TNFα-induced intercellular adhesion molecule 1 (ICAM-1) expression with an EC₅₀ of 0.631 µM. It (6-12 mg/kg) improves neurovascular injury after intracerebral hemorrhage in mice.

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