Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Quinidine Sulfate dihydrate

A P-glycoprotein substrate, Cytochrome P450 inhibitor
Catalog #: 2910
SKU-Size Size Price Qty
2910-1G 1 g
$45.00
2910-5G 5 g
$125.00
More Sizes Get Quote

Product Details

Alternate Name Conquinine; β-Quinine
Appearance White to off-white powder
CAS # 6591-63-5
Molecular Formula (C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O
Molecular Weight 782.9
Purity ≥97% by HPLC
Solubility DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
InChi InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
InChi Key ZHNFLHYOFXQIOW-WFTMRWCJSA-N
PubChem CID 16219922
MDL Number MFCD00149346
Handling Protect from light and moisture
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.