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PZ-2891

A potent and selective, orally active Pantothenate kinase (PANK) modulator
Catalog #: B2460

In stock

SKU-Size Size Price Qty
B2460-5 5 mg
$145.00
B2460-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name PZ2891; 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile
Appearance Crystalline solid
CAS # 2170608-82-7
Molecular Formula C₂₀H₂₃N₅O
Molecular Weight 349.44
Purity ≥98% by HPLC
Solubility DMSO
SMILES N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1
InChi InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3
InChi Key LGWDVWIZDPGCFG-UHFFFAOYSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PZ-2891 (PZ2891) a specific, allosteric, brain-permeable, pantothenate kinase (PANK) modulator. it acts as both an orthosteric inhibitor (IC₅₀ =1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.


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