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Pyrvinium Pamaote

A Cancer Stem cell (CSC) inhibitor
Catalog #: B1593
SKU-Size Size Price Qty
B1593-5 5 mg
$125.00
B1593-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate;2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine
Appearance Red solid
CAS # 3546-41-6
Molecular Formula C₇₅H₇₀N₆O₆
Molecular Weight 1151.42
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)[O-])[O-])C(=O)O
InChi InChI=1S/2C26H28N3.C23H16O6/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29)/q2*+1;/p-2
InChi Key OOPDAHSJBRZRPH-UHFFFAOYSA-L
PubChem CID 54680693
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pyrvinium pamoate (PP) is a quinoline-derived cyanine dye that displays anthelmintic properties and therapeutic function against animal-like protists such as Cryptosporidium parvum and Plasmodium falciparum. Pyrvinium also acts as a potent Wnt inhibitor. Pyrvinium has also shown to inhibit self-renewal of breast cancer stem cells (BCSCs) and decrease both CD44+CD24-/low and ALDH-positive BCSCs content in a panel of breast cancer cell lines.  


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