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Pyrroline-5-caroxylate reductase, M. tuberculosis Recombinant

Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Catalog #: P1456
SKU-Size Size Price Qty
P1456-10 100 µg
$195.00
P1456-50 50 µg
$785.00
More Sizes Get Quote

Product Details

Alternate Name P5CR, PCA reductase, P5C reductase, proC
Gene Symbol proC
Gene ID 887256
Accession # P9WHU7
Source E. coli
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight 49.4 kDa with N-terminal TRX tag
Purity by SDS-PAGE ≥90%
Biological Activity This enzyme has a specific activity of ≥ 7 mU/mg based on its conversion of proline to pyrroline-5-caboxylate.
Reconstitution Instructions Reconstitute the lyophilized protein with 30% Glycerol and 5 mM BME at the concentration of 0.5 mg/ml. Incubate the reconstituted protein at 25 °C for 15 minutes.
Amino Acid Sequence 1 – 295
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

P5CR catalyzes the NADH dependent reaction of converting pyrroline-5-caboxylate to proline. It is important for regulating amino acid metabolism, intracellular redox potential, and apoptosis. Increased P5CR expression and activity have been observed in carcinoma and pulmonary tumors.


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