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Pyridoclax

A potent Mcl-1 inhibitor
Catalog #: B1817

In stock

SKU-Size Size Price Qty
B1817-1 1 mg
$115.00
B1817-5 5 mg
$455.00

Product Details

Alternate Name (E)-3'-methyl-3''-styryl-3,2':5',2'':5'',3'''-quaterpyridine; MR29072
Appearance Crystalline solid
CAS # 1651890-44-6 
Molecular Formula C₂₉H₂₂N₄
Molecular Weight 426.51
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(N=CC(=C1)C2=C(C=C(C=N2)C3=CN=CC=C3)C=CC4=CC=CC=C4)C5=CN=CC=C5
InChi InChI=1S/C29H22N4/c1-21-15-27(20-32-28(21)25-10-6-14-31-18-25)29-23(12-11-22-7-3-2-4-8-22)16-26(19-33-29)24-9-5-13-30-17-24/h2-20H,1H3/b12-11+
InChi Key WGGSYXQFYRWBEC-VAWYXSNFSA-N
PubChem CID 92042827
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor (Kd = 25 nM).  Pyridoclax is able to disrupt BimL/Mcl-1 interaction in whole living cells.


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