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PYR-41

An irreversible ubiquitin-activating enzyme (E1) inhibitor
Catalog #: 1925
SKU-Size Size Price Qty
1925-5 5 mg
$90.00
1925-25 25 mg
$355.00
More Sizes Get Quote

Product Details

Alternate Name 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Appearance Brown solid
CAS # 418805-02-4
Molecular Formula C₁₇H₁₃N₃O₇
Molecular Weight 371.3
Purity ≥98% by TLC
Solubility DMSO (~25 mg/ml)
SMILES CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
InChi InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChi Key ARGIPZKQJGFSGQ-LCYFTJDESA-N
PubChem CID 5335621
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.


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