A potent histone deacetylase (HDAC) activity inhibitor
Catalog #: 2480 | abID:

Product Details

Alternate Name (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; Belinostat
Appearance White solid
CAS # 414864-00-9
Molecular Formula C₁₅H₁₄N₂O₄S
Molecular Weight 318.35
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
PubChem CID 6918638
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent histone deacetylase (HDAC) activity inhibitor. It inhibits HDAC activity in HeLa cell extracts with an IC₅₀ of 27 nM. Belinostat significantly increases acetylation of histones H3 and H4 and potently inhibits the growth of prostate cancer cell lines (IC₅₀ range from 0.5 to 2.5 µM) with cytotoxic activity preferentially against tumor cells.

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