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PX-478 hydrochloride

A HIF-1α inhibitor
Catalog #: B1033
SKU-Size Size Price Qty
B1033-5 5 mg
B1033-25 25 mg
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Product Details

Alternate Name (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
Appearance Brown solid
CAS # 685898-44-6
Molecular Formula C₁₃H₂₀Cl₄N₂O
Molecular Weight 394.11
Purity ≥98% by HPLC
Solubility H₂O (> 5 mg/ml)
SMILES C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
InChi InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
PubChem CID 11234794
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.

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