Product Details
| abID | ab146140 |
|---|---|
| Alternate Name | 2-[(1-Methylpropyl)dithio]-1H-imidazole; IV-2 |
| Appearance | Beige solid |
| CAS # | 141400-58-0 |
| Molecular Formula | C₇H₁₂N₂S₂ |
| Molecular Weight | 188.31 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mM) |
| SMILES | CCC(C)SSC1=NC=CN1 |
| InChi | InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9) |
| InChi Key | BPBPYQWMFCTCNG-UHFFFAOYSA-N |
| PubChem CID | 219104 |
| MDL Number | MFCD18086851 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α, VEGF and iNOS (IC₅₀ values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.
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