PX 12

An irreversible inhibitor of thioredoxin-1 (TRX-1)
Catalog #: 2217 | abID: ab146140

Product Details

abID ab146140
Alternate Name 2-[(1-Methylpropyl)dithio]-1H-imidazole; IV-2
Appearance Beige solid
CAS # 141400-58-0
Molecular Formula C₇H₁₂N₂S₂
Molecular Weight 188.31
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
InChi InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
PubChem CID 219104
MDL Number MFCD18086851
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α, VEGF and iNOS (IC₅₀ values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.

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