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Product Details
| Alternate Name | 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 58-58-2 |
| Molecular Formula | C₂₂H₂₉N₇O₅ · 2HCl |
| Molecular Weight | 544.43 |
| Purity | ≥98% by HPLC |
| Solubility | H₂O (~50 mg/ml) |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl |
| InChi | InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H |
| InChi Key | MKSVFGKWZLUTTO-UHFFFAOYSA-N |
| PubChem CID | 16757772 |
| MDL Number | MFCD00012691 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg/ml, while cells in suspension are sensitive to concentrations as low as 0.5 to 2 µg/ml.
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What is the recommended method of reconstitution? Once dissolved, what temperature should it be stored at and for how long can it be stored this way?
You can reconstitute Puromycin Dihydrochloride in water. Once reconstituted, it should be aliquoted abd stored at -20˚C in dark.
