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PTP1B Antibody (Clone 107AT531)

based on 1 citations in multiple journalsPTP1B Antibody (Clone 107AT531)14.1 4
Catalog #: 3122
$325.00

Product Details

Cat # +Size 3122-100
Size 100 µg
Antibody Target PTP1B
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Recombinant protein encoding amino acids 1-321 of human PTP1B
Accession # P18031
Gene ID 5770
Appearance Colorless liquid
Concentration 0.25 mg/ml
Formulation 100 µg (0.25 mg/ml) mouse monoclonal IgG1 antibody supplied in PBS with 0.09% (W/V) sodium azide.
Species Reactivity Human, mouse
Application ELISA, Western blot
Application & Usage The antibody can be used for ELISA (0.25 µg/ml) and Western blotting (0.5 – 2.5 µg/ml).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.


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Gan et al., IGF-1R Modulation of Acute GH-Induced STAT5 Signaling: Role of Protein Tyrosine Phosphatase Activity. Mol. Endocrinol., Nov 2013; 27: 1969 - 1979.
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