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PTP1B Antibody

Catalog #: 3174
$325.00

Product Details

Cat # +Size 3174-100
Size 100 µg
Antibody Target PTP1B
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein encoding amino acids 1-321 of human PTP1B
Accession # P18031
Gene ID 5770
Appearance Colorless liquid
Concentration 0.25 mg/ml
Formulation 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Affinity purified
Species Reactivity Human, mouse
Application ELISA, Western blot
Application & Usage The antibody can be used for ELISA (0.25 µg/ml), Western blotting (0.5 – 2.5 µg/ml).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.


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