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PTEN, human recombinant

A tumour supressor protein
Catalog #: 4838
$495.00

Product Details

Cat # +Size 4838-5
Size 5 μg
Alternate Name Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Gene Symbol PTEN
Gene ID 5728
Accession # P60484
Source E. coli
Appearance Liquid
Physical Form Description 100 µg/ml in 50 mM Tris-Acetate, pH 7.5, 150 mM NaCl, 0.1 mM EDTA, 10 mM glutathione, 25 mM DTT, 0.1 mM PMSF and 25% Glycerol.
Molecular Weight 80.0 kDa (GST tagged)
Purity by SDS-PAGE ≥90%
Endotoxin Level <0.1 ng/μg
Biological Activity A Phosphatase specific activity of ≥ 400 nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125 M in 20 mM Tris, pH 7.5, 150 mM NaCl, 50 M MgCl2, 0.05 % Tween-20, 0.2 % 2-mercaptoethano
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.


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