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Product Details
| Cat # +Size | 4838-5 |
|---|---|
| Size | 5 μg |
| Alternate Name | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del, |
| Gene Symbol | PTEN |
| Gene ID | 5728 |
| Accession # | P60484 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 100 µg/ml in 50 mM Tris-Acetate, pH 7.5, 150 mM NaCl, 0.1 mM EDTA, 10 mM glutathione, 25 mM DTT, 0.1 mM PMSF and 25% Glycerol. |
| Molecular Weight | 80.0 kDa (GST tagged) |
| Purity by SDS-PAGE | ≥90% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | A Phosphatase specific activity of ≥ 400 nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125 M in 20 mM Tris, pH 7.5, 150 mM NaCl, 50 M MgCl2, 0.05 % Tween-20, 0.2 % 2-mercaptoethano |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.
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