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A potent ad selective inhibitor of hypoxia inducible factor (HIF-2α)
Catalog #: B1920
SKU-Size Size Price Qty
B1920-5 5 mg
B1920-25 25 mg
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Product Details

Alternate Name (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile; PT2385
Appearance Crystalline solid
CAS # 1672665-49-4
Molecular Formula C₁₇H₁₂F₃NO₄S
Molecular Weight 383.34
Purity ≥98% by HPLC
Solubility DMSO
SMILES CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O
InChi InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
PubChem CID 91754484
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PT-2385 is a potent ad selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation, and tumor angiogenesis characteristic in clear cell renal cell carcinoma (ccRCC).

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