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based on 1 citations in multiple journalsPS4814.1 4
An allosteric PDK1 activator
Catalog #: 1869
SKU-Size Size Price Qty
1869-5 5 mg
1869-25 25 mg
1869-100 100 mg
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Product Details

Alternate Name (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
Appearance White to off-white solid
CAS # 1180676-32-7
Molecular Formula C₁₇H₁₅ClO₂
Molecular Weight 286.75
Purity ≥95% by HPLC
Solubility DMSO (100 mM) or EtOH (50 mM)
InChi InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
PubChem CID 44141940
MDL Number MFCD17215962
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.

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Aflaki et al., Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs. Science Translational Medicine, Jun 2014; 6: 240ra73.
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