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PRT4165

A potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro.
Catalog #: B1054
SKU-Size Size Price Qty
B1054-5 5 mg
$85.00
B1054-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione; NSC600157
Appearance Yellow solid
CAS # 31083-55-3
Molecular Formula C₁₅H₁₉NO₂
Molecular Weight 235.24
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O
InChi InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
InChi Key OMHZFEWYVFWVLI-UHFFFAOYSA-N
PubChem CID 207893
MDL Number MFCD00435709
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX. In addition, it prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α).


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