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Proteinase 3 (PR3), Human Neutrophil

Peptide with antibiotic and growth-promoting properties
Catalog #: 7290

Product Details

Cat # +Size 7290-25
Size 25 μg
Alternate Name AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
Gene Symbol AGP7
Gene ID 5657
Accession # P24158
Source Human Neutrophils
Appearance Frozen
Physical Form Description Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.
Molecular Weight 29 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.

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