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Propidium Iodide

based on 35 citations in multiple journalsPropidium Iodide355 4.7
A nucleic acid stain
Catalog #: 1056
$85.00

Product Details

Cat # +Size 1056-1
Size 1 ml
Alternate Name 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide, PI
Appearance Liquid
Formulation PBS ( 1 mg/ml)
CAS # 25535-16-4
Molecular Formula C₂₇H₃₄I₂N₄
Molecular Weight 668.39
SMILES CC[N+](C)(CC)CCC[N+]1=C2C=C(C=CC2=C3C=CC(=CC3=C1C4=CC=CC=C4)N)N.[I-].[I-]
InChi InChI=1S/C27H33N4.2HI/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20;;/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3;2*1H/q+1;;/p-1
InChi Key XJMOSONTPMZWPB-UHFFFAOYSA-M
PubChem CID 104981
MDL Number MFCD00011921
Handling Protect from light and moisture
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Propidium Iodide (PI) binds to double-stranded DNA, but it can only cross the plasma membrane of nonviable cells. When viewed using a fluorescence microscope with a rhodamine filter, cells that have lost membrane integrity will show red PI staining throughout the nuclei. For analysis by flow cytometry, the PI staining can be monitored in FL2 channel.


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Samuel T. Keating, The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan. Cell Rep., Apr. 2020;  32320649.
Zhihong Shao, CPNE1 predicts poor prognosis and promotes tumorigenesis and radioresistance via the AKT singling pathway in triple‐negative breast cancer. Mol Carcinog., Mar. 2020;  32181526.
Lili Dai, Resveratrol inhibits ACHN cells via regulation of histone acetylation. Pharm Biol., Mar. 2020; 32202448
Fei-Ting Hsu, Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF‐κB signalling participate in anti‐glioblastoma of imipramine. J Cell Mol Med., Mar. 2020; 32149465.
Samuel Fernández-Tomé, Inhibitory Effects of Peptide Lunasin in Colorectal Cancer HCT-116 Cells and Their Tumorsphere-Derived Subpopulation. Int J Mol Sci., Jan 2020;  31947688.
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