ProNGF, human recombinant

Neuronal apoptosis inducer
Catalog #: 4274 | abID:

Product Details

Alternate Name Beta-nerve growth factor (Beta-NGF)
Gene Symbol NGF
Gene ID 4803
Accession # P01138
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.
Molecular Weight ~25 kDA
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg (1 IEU/μg)
Reconstitution Instructions Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml.). This can further be diluted to other aqueous buffers.
Amino Acid Sequence Recombinant human ProNGF produced in E. coli is a non-glycosylated, non-covalently linked homodimer with each polypeptide chain containing 222 amino acids with an extra N-terminal Met and having a molecular mass of 25 kDa. The sequence of the first five N
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystine knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.

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