You have no items in your shopping cart.
Stat Inhibitors
STAT proteins also known as Signal Transducer and Activator of Transcription are transcription factors involved in a huge repertoire of biological signal transduction cascades leading to embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in organisms ranging from insects to man. There are seven mammalian STAT family members that have been identified: STAT1, 2, 3, 4, 5 and 6. They are responsible for conveying information from extracellular sources (e.g. receptor-ligand interaction at the cell surface) to the nucleus so that gene expression can be coordinated to external stimuli. Many growth factors, cytokines, hormones like insulin and their receptors relay intracellular signals through STAT proteins. Tyrosine kinases (for example: Janus Kinase/JAK) associated to the growth factor/cytokine receptors phosphorylate STAT proteins which results in their dimerization and transport into the nucleus followed by binding to target gene regulatory elements thus controlling gene expression. The STAT proteins can be dephosphorylated by nuclear phosphatases, which lead to their inactivation and they are transported out of the nucleus into the cytosol awaiting the next round of activation signal. Under normal physiological conditions, the activation of STATs is tightly regulated. In malignant cells however, STAT proteins become activated constitutively. Due to the versatility of the functional consequences of STAT-mediated signaling, they represent a potentially important target for drug development for a variety of human diseases. BioVision proudly offers an array of STAT inhibitors either directly acting on STAT proteins or other proteins playing critical roles in the STAT signaling pathway.
Stat Inhibitors Products
-
Cryptotanshinone
Catalog #: 2429 | DatasheetStarting at: $75.00
-
EZSolution™ Stat3 Inhibitor I, S3I-201
Catalog #: 2541 | Datasheet$95.00 -
Galiellactone
Catalog #: 2623 | DatasheetStarting at: $175.00
-
Lestaurtinib
Catalog #: 1805 | DatasheetStarting at: $90.00
-
Starting at: $130.00
-
$105.00
-
Niclosamide
Catalog #: 1826 | DatasheetStarting at: $80.00
-
PathwayReady™ JAK/STAT Signaling Inhibitor Panel
Catalog #: K864 | Datasheet$825.00 -
Starting at: $70.00
-
Resveratrol
Catalog #: 1758 | DatasheetStarting at: $60.00
-
Starting at: $75.00
-
Starting at: $125.00
-
Stat3 Activation Inhibitor, SPI
Catalog #: 1813 | Datasheet$165.00 -
Stat3 Inhibitor I, S3I-201
Catalog #: 1775 | DatasheetStarting at: $90.00
-
Stat3 Peptide Inhibitor, Cell-Permeable
Catalog #: 1778 | DatasheetStarting at: $165.00
-
Stat5 Inhibitor
Catalog #: 9484 | DatasheetStarting at: $65.00
-
Starting at: $75.00
