SIRT Inhibitors
Sirtuins (Silent mating-type Information regulator proteins) are a conserved family of proteins found in life forms ranging from bacteria to humans. Sirtuins are NAD+-dependent protein deacylases/deacetylases which remove acyl moieties from lysine-modified α-amino groups. In some cases, NAD+-dependent protein ADP-ribosylation is seen. There are seven mammalian sirtuins (SIRT1-7) that are segregated in different subcellular structures: nuclear sirtuins (SIRT1, -2, -6, -7), cytoplasmsis sirtuins (SIRT1 and SIRT2) and the mitochondrial sirtuins (SIRT3, -4 and -5). SIRT1 protects against neurodegeneration in Alzheimer's, Huntington's and Parkinson's diseases and acts as a redox sensor. Sirtuins affect a wide range of cellular processes like aging, transcription, apoptosis, inflammation, stress management as well as energy metabolism and alertness during nutrient deprivation. Sirtuins can also control circadian rhythm and synthesis of mitochondria (oxidative metabolism). Thus SIRT inhibitors are sought-after strategies for finding cures for a large number of human diseases. Potent inhibitors have been identified for SIRT1, 2, 3 and 5 (splitomicin, sirtinol, AGK2, cambinol, suramin, tenovin, salermide etc). SIRT1 inhibition could be a potential therapeutic approach in the treatment of cancer, HIV infections, Fragile X mental retardation syndrome and some parasitic diseases. SIRT2 inhibitors are implicated in the treatment of cancer and neurodegenerative diseases. BioVision's catalog includes several popular SIRT inhibitors for SIRT1, 2, 3, 5 and more.
