Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

BioVision Life Science Source
Menu

MAP Kinase-MEK Inhibitors

Mitogen-activated protein kinases (MAP kinases) are Serine/Threonine phosphorylating enzymes which function in a cascade typically involving at least 3 enzymes which get activated in a series by sequential phosphorylation events. These enzymes collectively coordinate cellular responses to various stimuli (growth factors or mitogens, cytokines, hormones, osmotic stress, heat-shock, viral infections) resulting in gene regulation (mRNA transcription and protein translation), immune reactions, cell division, differentiation, migration and programmed cell-death. This is why they are also called Extracellular signal-regulated kinases (ERKs). Any extracellular signal binding to the concomitant membrane receptor (typically a G-protein coupled receptor) is transduced via a GTPase resulting in activation of MAP3K (e.g. Raf), which in turn activates MAP2K (e.g. MEK1 and MEK2), which activates MAPK (e.g. ERK1, ERK2, p38 kinases, ERK5 etc.). Activated MAPK can relay the signal to a large array of downstream effector molecules including transcription factors. This can ultimately result in regulation of gene expression. Aberrant signaling through the MAPK pathway results in many of the hallmarks of cancer, including abnormal cellular proliferation, impaired apoptosis, increased angiogenesis, metastasis and the development of drug resistance. Thus participants in this pathway are appealing candidates for the development of new therapies to treat various malignancies. BioVision offers a collection of inhibitors targeting various steps of the MAPK pathway.


MAP Kinase/MEK Inhibitors

Items 1 to 50 of 53 total

per page

Page:
  1. 1
  2. 2

Items 1 to 50 of 53 total

per page

Page:
  1. 1
  2. 2
Categories: MAP Kinase-MEK Inhibitors
A-Z by Product Type
A-Z by Research Area
Support
Order Info
Company
BioVision, Inc.

BioVision, Inc., is a privately held Life Science company headquartered in the beautiful San Francisco Bay Area.

BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVision's products are currently being sold in more than 60 countries worldwide.

Company Profile

155 S Milpitas Blvd. Milpitas, CA 95035.
Tel: 408.493.1800
Fax: 408.493.1801
Toll Free: 800.891.9699 (US Only)
Tech Support: [email protected]
Sales Inquiries: [email protected]
Bulk Orders: [email protected]
Orders: [email protected]
COA Request: [email protected]
SDS Request: [email protected]

Privacy Policy
Copyright © 2018 BioVision Inc. All Rights Reserved.
All products are For Research Use Only. Not for use in diagnostic or therapeutic uses. Do not use in humans.
Payment methods