DYRK Inhibitors
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. The DYRK family consists of 5 members divided into two classes: Class I is comprised of DYRK1A and DYRK1B, whereas class II is comprised of DYRK2, DYRK3, and DYRK4. All DYRK proteins studied to date share common structural, biochemical, and functional properties with their ancestors in yeast. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease. BioVision is proud to offer nine (9) structurally divergent DYRK inhibitors for research.
