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CDK Inhibitors
Uncontrolled cellular proliferation mediated by the dysregulation of cell-cycle machinery and activation of cyclin-dependent kinases (CDKs) is the hallmark of cancer. Agents targeting CDKs have been considered as promising therapeutic targets in cancer treatment. Although the first-generation pan-CDK inhibitors failed in clinical trials because of their adverse events and low efficacy, most recently, a new generation of selective CDK4/6 inhibitors, including Ribociclib, Abemaciclib and Palbociclib, has shown potent efficacy with tolerable safety in preclinical and clinical studies. Recent approval of Palbociclib (Ibrance®) by the U.S. Food and Drug Administration (FDA) for the treatment of ER-positive and HER2-negative breast cancer demonstrates that CDK inhibitors with high selectivity profiles can have clinical utility for therapy based on individual tumor genetics. BioVision is proud to offer >25 potent and selective CDK inhibitors including Palbociclib (PD0332991), Abemaciclib (LY-2835219), Dinaciclib, and Ribociclib for research.
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(R)-Perharidine-1
Catalog #: 2615 | DatasheetStarting at: $105.00
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10Z-Hymenialdisine
Catalog #: 2212 | DatasheetStarting at: $175.00
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Starting at: $85.00
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Alsterpaullone
Catalog #: 1897 | DatasheetStarting at: $95.00
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Starting at: $125.00
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Aminopurvalanol A
Catalog #: 2205 | DatasheetStarting at: $60.00
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AT-7519 hydrochloride
Catalog #: 2816 | DatasheetStarting at: $95.00
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Starting at: $115.00
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Starting at: $135.00
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BS-181 dihydrochloride
Catalog #: B2180 | DatasheetStarting at: $115.00
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Butyrolactone I
Catalog #: 1690 | Datasheet$130.00 -
Starting at: $95.00
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Dinaciclib
Catalog #: 9537 | DatasheetStarting at: $125.00
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Flavopiridol
Catalog #: 2090 | DatasheetStarting at: $90.00
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Kenpaullone
Catalog #: 1904 | Datasheet$80.00 -
LY-2835219
Catalog #: B1039 | DatasheetStarting at: $125.00
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MSC-2530818
Catalog #: B1975 | DatasheetStarting at: $95.00
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Starting at: $145.00
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Starting at: $65.00
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Starting at: $145.00
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PD-0332991
Catalog #: 2843 | DatasheetStarting at: $95.00
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PD-0332991 isethionate
Catalog #: 9480 | DatasheetStarting at: $115.00
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RGB-286638, free base
Catalog #: 2886 | DatasheetStarting at: $165.00
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Ribociclib (LEE011)
Catalog #: 9481 | DatasheetStarting at: $95.00
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Starting at: $70.00
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Roscovitine
Catalog #: 1950 | DatasheetStarting at: $60.00
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Starting at: $145.00
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Starting at: $100.00
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THZ1 (Free base)
Catalog #: 9664 | DatasheetStarting at: $225.00
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THZ1 hydrochloride
Catalog #: 9544 | DatasheetStarting at: $235.00
