Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Aurora Kinase Inhibitors

Aurora kinases are a highly conserved family of enzymes which add phospho-groups to Serine/Threonine residues of substrate proteins functioning in chromatid segregation during cell division. The human aurora kinase family comprises three members: Aurora A, B and C (AURKA, AURKB and AURKC). Aurora A is important in centrosome function and duplication, mitotic entry and bipolar spindle assembly. Aurora B is the catalytic component of the chromosomal passenger complex which coordinates events during segregation of the chromatids during mitosis, histone modification (epigenetic regulation) and cytokinesis. Aurora C is expressed in testes cells and is believed to be important for chromosome segregation during meiosis. The involvement of these kinases in cell division and deregulated expression of aurora A and B in tumor cells (often resulting in genetic aberrations and thus leading to malignancy) together provided the incentive to identify and test small-molecule inhibitors of these kinases. Many of these inhibitors are undergoing preclinical and clinical trials: MK-0457 (VX-680), AZD1152-HQPA, PHA-739358. MLN8054 was the first orally administered Aurora A kinase selective inhibitor to be tested in human clinical trials for the treatment of colorectal cancer. BioVision proudly offers several aurora kinase inhibitors including the ones mentioned above and more.


Aurora Kinase Inhibitors Products

14 Item(s)

per page

14 Item(s)

per page

$
Subscribe to our Newsletter!!
and automatically get enrolled into a raffle to win Google Home.
Offer valid for US customers only.