Ferroptosis Inhibitors
Death by metal: a hidden detonator inside cancer cells? Our cells are wired to explode. Controlled cell death is vital, making it a part of life. Apoptosis, necrosis, and autophagy are the primary mechanisms of cell death, each having a distinct biochemical and morphological footprint. "Ferroptosis" is proposed to describe a process of cell death that doesn't conform to these footprints. In this case, cell death results from an iron-dependent accumulation of lipid reactive oxygen species (ROS) and this requirement for ROS accumulation is universal. Furthermore, ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically very distinct from apoptosis, necrosis, and autophagy. Inhibition of such cell death has the potential to protect organisms from neurodegeneration. Biovision is very excited to offer the Ferroptosis inhibitors which are highly pure, cell permeable and can be used in in vitro studies.
