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Caspase
Caspases are responsible for the deliberate disassembly of the cell into apoptotic bodies during apoptosis. Caspases are present as inactive pro-enzymes that are activated by proteolytic cleavage. Caspases 8, 9, 12 and 3 are situated at pivotal junctions in apoptosis pathways. Caspase 8 initiates disassembly in response to extracellular apoptosis-inducing ligands and is activated in a complex associated with the cytoplasmic death domain of many cell surface receptors for the ligands. Caspase 9 activates disassembly in response to agents or insults that trigger the release of cytochrome c from mitochondria and is activated when complexed with apoptotic protease activating factor 1 (APAF-1) and extra-mitochondrial cytochrome c. Caspase-12 appears to be activated by ER stress. All three caspase pathways lead to caspase-3 activation. Caspase 3 amplifies caspase 8, caspase 9, and caspase-12 initiation signals into full-fledged commitment to disassembly. Caspase 8 and caspase 9 activate caspase 3 by proteolytic cleavage and caspase 3 then cleaves vital cellular proteins or other caspases.
Caspase Products
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AIF Antibody
Catalog #: 3202 | DatasheetStarting at: $89.00
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Anti-PARP Antibody (2B6)
Catalog #: A1109 | Datasheet$285.00 -
Apaf-1 Antibody
Catalog #: 3018 | Datasheet$265.00 -
Bid Antibody
Catalog #: 3172 | DatasheetStarting at: $89.00
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Caspase-1 Antibody
Catalog #: 3019 | DatasheetStarting at: $89.00
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Caspase-11 Antibody
Catalog #: 3021 | DatasheetStarting at: $89.00
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Caspase-12 Antibody
Catalog #: 3282 | DatasheetStarting at: $89.00
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Caspase-2 Antibody
Catalog #: 3027 | DatasheetStarting at: $89.00
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Caspase-3 (Active) Antibody
Catalog #: 3015 | DatasheetStarting at: $150.00
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Caspase-3 Antibody
Catalog #: 3138 | DatasheetStarting at: $89.00
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Caspase-3 Antibody (Clone C33)
Catalog #: 3004 | Datasheet$310.00 -
Caspase-4 Antibody
Catalog #: 3028 | DatasheetStarting at: $89.00
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Caspase-5 Antibody
Catalog #: 3029 | DatasheetStarting at: $89.00
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Caspase-6 (Active) Antibody
Catalog #: 3156 | Datasheet$365.00 -
Caspase-6 Antibody
Catalog #: 3256 | DatasheetStarting at: $89.00
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Caspase-7 Antibody
Catalog #: 3135 | DatasheetStarting at: $89.00
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Caspase-8 Antibody
Catalog #: 3158 | DatasheetStarting at: $89.00
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Caspase-8 Antibody
Catalog #: 3020 | DatasheetStarting at: $89.00
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Caspase-8 Antibody (Clone C502S)
Catalog #: 3258 | Datasheet$365.00 -
Caspase-9 (Active) Antibody
Catalog #: 3149 | Datasheet$405.00 -
Caspase-9 Antibody
Catalog #: 6670 | DatasheetStarting at: $89.00
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Caspase-9 Antibody
Catalog #: 3136 | DatasheetStarting at: $89.00
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Caspase-9 Antibody
Catalog #: 3016 | DatasheetStarting at: $89.00
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Caspase-9 Antibody
Catalog #: 3409 | DatasheetStarting at: $89.00
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Cathepsin K Antibody
Catalog #: 3588 | DatasheetStarting at: $89.00
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Cathepsin L Antibody
Catalog #: 3192 | DatasheetStarting at: $89.00
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Cathepsin S Antibody
Catalog #: 3366R | DatasheetStarting at: $89.00
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Cathepsin V Antibody
Catalog #: 3712 | DatasheetStarting at: $89.00
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cIAP-1/HIAP-2 Antibody
Catalog #: 3180 | DatasheetStarting at: $89.00
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Cytochrome c Antibody
Catalog #: 3353 | DatasheetStarting at: $89.00
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Cytochrome c Antibody
Catalog #: 3352 | DatasheetStarting at: $89.00
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Cytochrome c Antibody (Clone 7H8.2C12)
Catalog #: 3026 | Datasheet$365.00 -
Lamin A Antibody
Catalog #: 3267 | DatasheetStarting at: $89.00
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PARP Antibody
Catalog #: 3002 | DatasheetStarting at: $89.00
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PARP Antibody (Clone 10H)
Catalog #: 3000 | Datasheet$295.00 -
PARP Antibody (Clone 7A10)
Catalog #: 3023 | Datasheet$325.00
