JAK Inhibitors
Janus Kinases (JAKs) are enzymes that phosphorylate Tyrosine residues on target proteins primarily acting as a signal transducer in the JAK-STAT signaling pathway which plays a key role in the synthesis of blood cells as well as cell growth, immune and inflammatory responses in the body. There are four members of the JAK family: JAK-1, 2, 3 and Tyrosine Kinase 2 (TYK2). Under normal physiological conditions, the JAK/STAT pathway transmits signals initiated by blood cell growth factors, cytokines (interleukins and interferons) or hormones from the outside of a bone marrow stem cell to its nucleus and ultimately results in differential regulation of target gene transcription. This signaling cascade ensures proper blood cell development and function, as well as balanced inflammatory responses based on the external stimuli. Defects or overactivity in this pathway are thought to cause myeloproliferative neoplasms (MPN), a group of diseases in which specific types of blood cells are overproduced and their functioning is disrupted. JAK inhibitors are under development for the treatment of many diseases stemming from either abnormalities in blood cell formation and development or inflammation: psoriasis, rheumatoid arthritis, polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. BioVision's product portfolio includes not just a broad selection of JAK inhibitors but a chosen collection of inhibitors targeting various participants in the JAK/STAT signaling cascade in a convenient set.
JAK Inhibitors
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Starting at: $195.00
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Starting at: $145.00
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Starting at: $55.00
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Baricitinib
Catalog #: 2842 | DatasheetStarting at: $115.00
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Baricitinib phosphate
Catalog #: 2841 | DatasheetStarting at: $115.00
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Starting at: $135.00
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BMS-911543
Catalog #: 2630 | DatasheetStarting at: $85.00
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Starting at: $145.00
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Cerdulatinib
Catalog #: 2803 | DatasheetStarting at: $115.00
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Starting at: $165.00
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Starting at: $150.00
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CP-690550 citrate
Catalog #: 9428 | DatasheetStarting at: $145.00
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Starting at: $55.00
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Decernotinib (VX-509)
Catalog #: B1260 | DatasheetStarting at: $115.00
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DiscoveryPak™ JAK Inhibitors Set
Catalog #: S236 | Datasheet$775.00 -
EZSolution™ Baricitinib
Catalog #: B2480 | Datasheet$85.00 -
EZSolution™ Cerdulatinib
Catalog #: B2482 | Datasheet$125.00 -
EZSolution™ CP-690550
Catalog #: B2478 | Datasheet$165.00 -
EZSolution™ Cyt387
Catalog #: B2484 | Datasheet$230.00 -
EZSolution™ Decernotinib (VX-509)
Catalog #: B2621 | Datasheet$125.00 -
EZSolution™ Fedratinib (TG101348)
Catalog #: B2487 | Datasheet$265.00 -
EZSolution™ Filgotinib
Catalog #: B2481 | Datasheet$95.00 -
EZSolution™ LY-2784544
Catalog #: B2483 | Datasheet$135.00 -
EZSolution™ Pacritinib
Catalog #: B2485 | Datasheet$125.00 -
EZSolution™ Peficitinib
Catalog #: B2623 | Datasheet$85.00 -
EZSolution™ PF-03394197
Catalog #: B2479 | Datasheet$155.00 -
EZSolution™ PF-04965842
Catalog #: B2622 | Datasheet$125.00 -
EZSolution™ Ruxolitinib
Catalog #: B2477 | Datasheet$155.00 -
EZSolution™ABT-494 (Upadacitinib)
Catalog #: B2486 | Datasheet$205.00 -
Filgotinib
Catalog #: 2871 | DatasheetStarting at: $145.00
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GLPG0634 Analog
Catalog #: B1836 | DatasheetStarting at: $115.00
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Starting at: $145.00
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LY-2784544
Catalog #: B1914 | DatasheetStarting at: $125.00
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$105.00
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NVP-BSK805 dihydrochloride
Catalog #: B2200 | DatasheetStarting at: $75.00
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PathwayReady™ JAK/STAT Signaling Inhibitor Panel
Catalog #: K864 | Datasheet$825.00 -
Peficitinib
Catalog #: B2474 | DatasheetStarting at: $75.00
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PF-03394197
Catalog #: 2883 | DatasheetStarting at: $145.00
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PF-04965842
Catalog #: B2470 | DatasheetStarting at: $115.00
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Ruxolitinib phosphate
Catalog #: B2631 | DatasheetStarting at: $95.00
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Ruxolitinib, Free base
Catalog #: 2139 | DatasheetStarting at: $145.00
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Starting at: $125.00
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SB1317 (TG-02)
Catalog #: B3218 | DatasheetStarting at: $115.00
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Starting at: $165.00
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Starting at: $75.00
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Starting at: $65.00
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Tyrphostin AG 490
Catalog #: 1570 | Datasheet$100.00 -
Starting at: $130.00
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Starting at: $75.00
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Starting at: $100.00