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Bruton's Tyrosine Kinase (BTK) Inhibitors
Bruton's tyrosine kinase (BTK), also known as agammaglobulinemia tyrosine kinase (ATK) or B-cell progenitor kinase (BPK), is a non-receptor tyrosine kinase that was initially identified as the defective protein in human X-linked agammaglobulinemia (XLA). BTK is a member of the Tec family of protein tyrosine kinases and plays a major role in B-lymphocyte development, differentiation, and signaling. Mutations in the Btk gene lead to X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Activation of Btk triggers a cascade of signaling events that culminates in the generation of calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kB) and nuclear factor of activated T cells (NFAT). Inhibition of BTK will be of therapeutic significance in the treatment of both B cell-related hematological cancers (e.g. non-Hodgkin lymphoma (NHL) and B cell chronic lymphocytic leukemia (B-CLL), and autoimmune diseases (e.g. rheumatoid arthritis). BioVision is pleased to offer a number of small molecule BTK inhibitors for research.
Bruton's Tyrosine Kinase (BTK) Inhibitors Products
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Acalabrutinib
Catalog #: B1193 | DatasheetStarting at: $95.00
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AVL-292 (Spebrutinib)
Catalog #: 9413 | DatasheetStarting at: $85.00
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BTK Inhibitor, CNX-774
Catalog #: 2600 | DatasheetStarting at: $125.00
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BTK Inhibitor, PCI-32765
Catalog #: 2298 | DatasheetStarting at: $135.00
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Starting at: $130.00
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Evobrutinib
Catalog #: B2379 | DatasheetStarting at: $165.00
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Starting at: $155.00
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Starting at: $95.00
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Starting at: $125.00
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ONO-4059 analog
Catalog #: B1897 | DatasheetStarting at: $145.00
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Starting at: $75.00
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Starting at: $135.00
