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Aurora Kinase Inhibitors
Aurora kinases are a highly conserved family of enzymes which add phospho-groups to Serine/Threonine residues of substrate proteins functioning in chromatid segregation during cell division. The human aurora kinase family comprises three members: Aurora A, B and C (AURKA, AURKB and AURKC). Aurora A is important in centrosome function and duplication, mitotic entry and bipolar spindle assembly. Aurora B is the catalytic component of the chromosomal passenger complex which coordinates events during segregation of the chromatids during mitosis, histone modification (epigenetic regulation) and cytokinesis. Aurora C is expressed in testes cells and is believed to be important for chromosome segregation during meiosis. The involvement of these kinases in cell division and deregulated expression of aurora A and B in tumor cells (often resulting in genetic aberrations and thus leading to malignancy) together provided the incentive to identify and test small-molecule inhibitors of these kinases. Many of these inhibitors are undergoing preclinical and clinical trials: MK-0457 (VX-680), AZD1152-HQPA, PHA-739358. MLN8054 was the first orally administered Aurora A kinase selective inhibitor to be tested in human clinical trials for the treatment of colorectal cancer. BioVision proudly offers several aurora kinase inhibitors including the ones mentioned above and more.
Aurora Kinase Inhibitors Products
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Starting at: $325.00
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Starting at: $135.00
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Aurora Kinase B Inhibitor (AZD1152-HQPA)
Catalog #: 1583 | DatasheetStarting at: $205.00
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CCT-129202
Catalog #: B1934 | DatasheetStarting at: $85.00
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CCT-137690
Catalog #: B1935 | DatasheetStarting at: $125.00
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Starting at: $115.00
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Danusertib
Catalog #: B1937 | DatasheetStarting at: $165.00
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Starting at: $135.00
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EZSolution™ Tozasertib
Catalog #: 1803 | Datasheet$100.00 -
GSK-1070916
Catalog #: B1939 | DatasheetStarting at: $165.00
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Hesperadin
Catalog #: B1940 | DatasheetStarting at: $185.00
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JNJ-7706621
Catalog #: B1941 | DatasheetStarting at: $85.00
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Starting at: $195.00
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Starting at: $95.00
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Starting at: $135.00
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Starting at: $165.00
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PF-03814735
Catalog #: B1257 | DatasheetStarting at: $175.00
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PHA-680632
Catalog #: B1944 | DatasheetStarting at: $185.00
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Starting at: $50.00
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Starting at: $85.00
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Starting at: $125.00
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Starting at: $185.00
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Starting at: $135.00
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Tozasertib (VX-680, MK-0457, VX6)
Catalog #: 1595 | DatasheetStarting at: $100.00
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Tripolin A
Catalog #: 2307 | DatasheetStarting at: $125.00
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Starting at: $80.00
