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Dipeptidyl peptidase-4 (DPP-4) Inhibitors

Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that is encoded by the DPP4 gene in humans. DPP4 enzyme is expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. It appears to work as a suppressor in the development of cancer and tumors and is useful as a marker for various cancers, with its levels differentially regulated on the cell surface or in the serum in various neoplasmsDPP4 inhibitors have emerged as a new class of oral antidiabetic agents. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels. Several DPP-4 inhibitors are in clinical development. The different DPP-4 inhibitors are distinctive in their metabolism (saxagliptin and vildagliptin are metabolized in the liver and sitagliptin is not) and their excretion. BioVision has a multitude of such inhibitors for basic and preclinical research.


Dipeptidyl peptidase-4 (DPP-4) Inhibitors Products

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