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Enzyme Inhibitors
Enzymes are biological catalysts that drive various reactions within a cell. They are required for nearly every function of a living cell/organism from digestion of food to the synthesis of DNA. Enzymes are usually very specific as to which reactions they catalyze and the substrates that are involved. Enzyme activity can be modulated by different classes of molecules. Enzyme Inhibitors are molecules that bind to the enzyme and decrease or completely stop their function. Since blocking the activity of an enzyme can have profound effects on the downstream cellular events sometimes with pathological or disease consequences, enzyme inhibition is a crucial component of new drug design. The discovery of new and potent enzyme inhibitors and developing better classes of inhibitors constitutes a dynamic branch of biochemical and pharmacological research.
An enzyme inhibitor can work in many different ways. The binding of an inhibitor can stop a substrate from entering the active site of the enzyme and/or prevent the enzyme from catalyzing its reaction. Inhibitor binding can be either reversible or irreversible. Reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether these inhibitors bind to the enzyme (competitive inhibition), the enzyme-substrate complex (uncompetitive inhibition), or both (non-competitive inhibition and mixed inhibition). Irreversible inhibitors, on the other hand, usually react with the enzyme via covalent bond formation and change the enzyme structure permanently. Small molecule inhibitors functioning in regulating and reprogramming the pathways governing the fate of a cell has revolutionized stem-cell research in the last few years.
In a nutshell, different types of inhibitors are being used to answer an increasing array of questions in biological and pharmaceutical research leading to discovery of new drugs or improvement of existing drugs eventually enhancing treatment options for human diseases like HIV, cancer, Diabetes, Alzheimer's the list being ever-increasing. BioVision offers a comprehensive collection of more than 1800 enzyme inhibitors covering all the core biological/pharmacological research areas. These inhibitors are listed based on the enzyme/pathway they work on.
An enzyme inhibitor can work in many different ways. The binding of an inhibitor can stop a substrate from entering the active site of the enzyme and/or prevent the enzyme from catalyzing its reaction. Inhibitor binding can be either reversible or irreversible. Reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether these inhibitors bind to the enzyme (competitive inhibition), the enzyme-substrate complex (uncompetitive inhibition), or both (non-competitive inhibition and mixed inhibition). Irreversible inhibitors, on the other hand, usually react with the enzyme via covalent bond formation and change the enzyme structure permanently. Small molecule inhibitors functioning in regulating and reprogramming the pathways governing the fate of a cell has revolutionized stem-cell research in the last few years.
In a nutshell, different types of inhibitors are being used to answer an increasing array of questions in biological and pharmaceutical research leading to discovery of new drugs or improvement of existing drugs eventually enhancing treatment options for human diseases like HIV, cancer, Diabetes, Alzheimer's the list being ever-increasing. BioVision offers a comprehensive collection of more than 1800 enzyme inhibitors covering all the core biological/pharmacological research areas. These inhibitors are listed based on the enzyme/pathway they work on.
Enzyme Inhibitors Categories
- Enzyme Inhibitors (A-Z)
- ACAT Inhibitors
- ACC Inhibitors
- Adenylase Cyclase Inhibitors
- Aldo-Keto Reductase (AKR) Inhibitors
- Androgen Receptor Antagonists
- Angiogenesis Inhibitors
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme (ACE) Inhibitors
- Arginase Inhibitors
- Aromatase Inhibitors
- ATP Citrate Lyase Inhibitors
- ATPase Inhibitors
- Autophagy Inhibitors
- Bcl-2 Inhibitors
- BMP Inhibitors
- Bone Resorption Inhibitors
- Bromodomain Inhibitors
- Calpain Inhibitors
- Caspase & Granzyme B Inhibitors
- Cathepsin Inhibitors
- CDc42 Inhibitors
- Cell Adhesion Inhibitors
- CETP Inhibitors
- Chloride Channel Blockers
- Cholesterol Transport Inhibitor
- Cyclooxygenase (COX) Inhibitors
- Dipeptidyl Peptidase Inhibitors
- DNA Ligase Inhibitors
- DprE1 Inhibitors
- DUBs (Deubiquitinating Enzymes) and related Inhibitors
- Elastase Inhibitors
- FAAH Inhibitors
- Farnesyl Protein Transferase (FPT) Inhibitors
- Fatty Acid Synthase (FAS) Inhibitors
- Ferroptosis Inhibitors
- FLAP (5-Lipoxygenase-activating protein) Inhibitors
- Glucosidase Inhibitors
- GLUT1 Inhibitors
- Glutamate Receptor Antagonists
- Glutamate Uptake Inhibitors
- Glycolysis Inhibitors
- GST Inhibitors
- GTPase Inhibitors
- Guanylate Cyclase Inhibitors
- Heat Shock Protein (Hsp) Inhibitors
- Hedgehog (Hh) Signaling Pathway Antagonists
- HIF Inhibitors
- HIF-PH Inhibitors
- Histone Acetyltransferase (HAT) Inhibitors
- Histone Deacetylase (HDAC) Inhibitors
- Histone Demethylase (HDM) Inhibitors
- HIV Integrase Inhibitors
- HMG-CoA Inhibitors
- Indoleamine 2,3-dioxygenase (IDO) Inhibitors
- Inflammasome Inhibitors
- Isocitrate Dehydrogenase (IDH) Inhibitors
- KMO (Kynurenine 3-monoxygenase) Inhibitors
- Lactate Dehydrogenase (LDH) Inhibitors
- Lipase Inhibitors
- Lipoxygenase (LO) Inhibitors
- Matrix Metalloproteinase (MMP) Inhibitors
- MDM2 Inhibitors
- Methyltransferase Inhibitors
- Microtubule Inhibitors
- MIF Antagonists
- Mitochondrial Division Inhibitors
- Mitochondrial Electron Transport Chain Inhibitors
- Monoamine oxidase (MAO) Inhibitors
- Multidrug Resistance (MDR) Inhibitors
- Myeloperoxidase (MPO) Inhibitors
- NAALADase Inhibitors
- Nampt Inhibitors
- Necroptosis and Necrosis Inhibitors
- NF-KB Pathway Inhibitors
- Nitric Oxide Synthase (NOS) Inhibitors
- NLRP3 Inflammasome inhibitors
- Nuclear Export Inhibitors
- p53 Inhibitors
- 15-PGDH Inhibitors
- PCSK9 Inhibitors
- Phosphatase Inhibitors
- Phosphodiesterase (PDE) Inhibitors
- Phospholipase Inhibitors
- Poly (ADP-ribose) Polymerase (PARP) Inhibitors
- PPAR Antagonists
- Protease Inhibitors
- Proteasome Inhibitors
- Protein Arginine Deiminase (PAD) Inhibitors
- Protein Kinase Inhibitors
- Protein-Protein Interaction (PPI) Inhibitors.
- PTEN Inhibitors
- Rac1 Inhibitors
- Renin Inhibitors
- S-Adenosyl-L-homocysteine (SAH) hydrolase inhibitors
- SCD1 Inhibitors
- Secretase Inhibitors
- SGLT-2 Inhibitors
- SIRT Inhibitors
- Smad Inhibitors
- Sodium Channel Modulators
- Sphingosine Kinase (SK) Inhibitors
- SREBP Activation Inhibitors
- Stat Inhibitors
- STING Inhibitors
- SUMOYlation Inhibitors
- TACE Inhibitors
- Tankyrase Inhibitors
- Thioredoxin inhibitors
- Topoisomerase Inhibitors
- Ubiquitin Activating Enzyme E1 Inhibitor
- Ubiquitin Ligase (E3) Inhibitors
- Ubiquitin Proteasome Pathway Inhibitors
- VCP-p97 Inhibitors
- Wnt Signaling Inhibitors
- Other Inhibitors
