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STING Ligands
Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal transducer and activator of transcription 6) signaling pathways to induce robust type I interferon and proinflammatory cytokine responses. STING is known to be a central mediator of innate immunity. When stimulated, STING induces the expression of type I interferon, cytokines and T cell recruitment factors that result in the activation of macrophages and dendritic cells, innate effector cells such as natural killer (NK) cells, and priming of tumor-specific T cells. The development of compounds that modulate STING has recently been the focus of intense research for the treatment of cancer and infectious diseases and as vaccine adjuvants.
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cGAMP disodium salt
Catalog #: 2435 | Datasheet$135.00 -
Starting at: $85.00
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Cyclic-di-GMP
Catalog #: B2045 | DatasheetStarting at: $145.00
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Starting at: $155.00
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Starting at: $135.00
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STING Agonist C11
Catalog #: B2398 | DatasheetStarting at: $125.00
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STING AGONIST G10
Catalog #: B2047 | DatasheetStarting at: $125.00
